New Medicine Articles Abt Dr. Gedde Contact Home



Dr. Gedde's Credentials

Dr. Margaret Gedde is a Stanford-trained MD PhD pathologist and award-winning researcher who worked for years developing drugs in the pharmaceutical industry.

In 2004, Dr. Gedde left that industry to open an alternative medical practice focused on holistic, supportive, non-pharmaceutical therapies that can offer large benefits to patients but are not accepted by conventional medicine.

Currently Dr. Gedde specializes in the use of cannabis, a plant-based therapy, to help patients get healthier, get off the pills and have better quality of life.

Healing Philosophy          Full Curriculum Vitae


  • BA, Biochemistry, Columbia University, 1981
  • MD, Stanford University, 1993
  • PhD, Biophysical Chemistry, Stanford University, 1993
  • Residency, Pathology & Laboratory Medicine, University of Pennsylvania, 1993-1997
  • Board Certification, Clinical Pathology, 1997
  • Howard Hughes Medical Institute Physician Postdoctoral Fellow, 1996-1999
  • Postdoctoral Fellowship, University of California at Berkeley, 1997-1999
  • Additional research at world class institutions including The Rockefeller University and Sloan-Kettering Cancer Institute. Total of a dozen years in molecular biology, microbiology, protein chemistry, biochemistry and biophysics research
  • Pharmaceutical development director and consultant 1999-2004. I left this work after discovering cheating in a drug development program.
  • Holistic, integrative doctor through my medical practice Gedde Whole Health:
    • Maui, Hawaii – 2004
    • Salida, Colorado – 2004-2013
    • Colorado Springs, Colorado – 2011-present
    • Buena Vista, Colorado – 2013-present

From the Desk of
Dr. Margaret Gedde, MD, PhD

Dear Health Seeker,

I am a Stanford-trained medical doctor and scientist who worked in the pharmaceutical industry and who now specializes in the medical use of cannabis - medical marijuana.

This holistic, plant-based therapy helps people with chronic pain and other conditions get off the pills and enjoy better health and quality of life.

How did I go from mainstream medicine to specializing in medical marijuana? Here’s some of my journey.

Before medical school, I found the ideas of other pioneer alternative healers like Adele Davis and Paavo Airola deeply inspiring. Yet during my medical education, I often heard alternative health practitioners like chiropractors and acupuncturists referred to as "quacks".

Within the hierarchical, pharmaceutical-based, control paradigm world of conventional medicine, I learned to keep my unconventional ideas to myself - and eventually to set them aside.

Aiming high, I obtained MD and PhD degrees and Board Certification. I enjoyed prestigious research grants and soaked up the environment of world-class institutions, then went to work on the clinical development of pharmaceutical drugs.

I was accomplished and well-paid – but was thoroughly disconnected from what supports vibrant health.

In the pharmaceutical industry though, it started to seep in that the goals of the companies I worked for were not the same as mine.

It should not have been a shock when I “got” that decisions were made to maximize corporate profit, and not to maximize patients’ best interests – but it was.

When management proposed taking shortcuts on a drug program I was working on, I had had enough. I left that industry with a desire to learn about therapies that were the best for patients, regardless of the corporate bottom line.

Fortunately, at that time I had a general practice blessed with patients seeking therapies that supported the body and respected its intelligence and power to heal.

Working to help my patients, I met and learned from practitioners who used alternative methods like targeted nutritional therapy, therapeutic tissue cleansing, vibrational healing, herbal medicine, bioidentical hormone therapy and subject after subject I had never heard of in medical school.

My clinics ultimately came to focus on the medical use of cannabis – a plant-based therapy that offers better relief at far less risk than any pharmaceutical in treatment of chronic pain, nausea and other conditions.

Every day, I am inspired by helping people use this ancient therapy to relieve their pain, improve their health, get off the pills and get their lives back.

Could medical marijuana help you? Looking forward to seeing you in clinic!

Margaret Gedde, MD, PhD

Full Curriculum Vitae


  • 1981 - B.A. Barnard College, Columbia University (Biochemistry) Cum Laude
  • 1993 - M.D. Stanford University School of Medicine
  • 1993 - Ph.D. Stanford University Department of Chemistry (Biophysical Chemistry)

Clinical Experience

1993 to 1997
University of Pennsylvania Medical Center, Philadelphia, PA
Resident and Clinical Instructor,
Division of Laboratory Medicine,
Department of Pathology and Laboratory Medicine

1994 to 1995
Chief Resident, Division of Laboratory Medicine

Board Certification, Clinical Pathology

  • Trained in all areas of the clinical laboratory (including molecular diagnostics, hematology, immunology, coagulation, transfusion medicine, microbiology and chemistry), with emphasis of diagnosis and therapy of leukemias and lymphomas.
  • Worked with virtually all clinical services and therapeutic areas in the hospital through consultations, nightly call, and clinical rounds. Duties included administering transfusion therapies on the oncology and bone marrow transplant services.
  • As Chief Resident, I led morning resident rounds, organized didactic and journal club series, and was liaison to the administration, facilitating two-way communication between faculty and residents. I addressed resident complaints and practiced conflict resolution. Organizational duties included planning resident schedules and budgeting program expenses.
  • To improve the quality of the clinical pathology resident service, I spearheaded an initiative to completely revise the Clinical Pathology Resident On Call Manual, and negotiated the purchase of new computers.
  • As Clinical Instructor, I taught General Pathology as well as advanced topics to medical students for three years, was invited to design and give a course on laboratory testing for nurses, and published two continuing education articles.
  • In recognition of my research accomplishments, I was asked to speak as part of a departmental presentation to the new Chairman of the Board of Trustees of the University of Pennsylvania.
  • Memorably, my Chief Resident counterpart in Anatomic Pathology and I recruited the help of the residency director and department chair to address tensions that had arisen between residents of different national backgrounds. Though some people we talked to thought we should stay away from the issue entirely, we believed it best to address these tensions openly. Our efforts culminated in a specially-called meeting of residents and faculty, where the tensions were resolved. I am proud that this resulted in a healthier working environment for all residents.

2003 – 2004
Solo General Practice, Maui, Hawaii

  • Provided basic medical care in a small general practice, consulting with specialists and coordinating treatment as needed. Advocated for patient interests within established medical structures such as HMOs.
  • Special interest in protocols for cleansing/detoxification and for neurotransmitter rebalancing, for patients experiencing chronic illness.

Silky Skin Laser Spa, Maui, Hawaii
Medical Director

  • Provided laser hair removal and other aesthetic treatments to client-patients in a relaxing and beautiful medical spa environment.
  • Worked hand-in-hand with owners to address medical-legal questions while developing a viable business model in the demanding Maui market.
  • Developed and implemented a successful marketing program that included phone contacts, promotions, print and radio ads, door-to-door contact, and a web presence. Competitive edge was based on an innovative concept, a high degree of professionalism, and close attention to client needs.
  • Clients showed high levels of loyalty; for example, after the owners chose to relocate the business in Colorado, one client elected to receive a follow up treatment at the new location, though it meant she had to travel from Maui to Colorado, and though numerous other practices offering the treatment were available to her.

2004 to present
Medical Practice in Salida, CO

Pharmaceutical Industry Experience

1999 to 2004
Worked at the Director level as an employee then as an independent consultant in pharmaceutical research and development.

I am presently blackballed in the pharmaceutical industry for resigning in protest of drug development cheating regarding a new antibiotic with potential pandemic and anti-terror uses.

Because of this I no longer provide details of my pharmaceutical development experience on my websites.

Medical and Basic Science

1995 to 1997
University of Pennsylvania School of Medicine, Philadelphia, PA
Postdoctoral Fellow, Department of Microbiology

1997 to 1999
University of California at Berkeley, Berkeley, CA
Postdoctoral Fellow, Department of Molecular and Cell Biology
Advisor: Daniel A. Portnoy

1996 to 1999
Howard Hughes Medical Institute Physician Postdoctoral Fellow

  • Demonstrated that the pH-dependence of listeriolysin O (a pore-forming toxin made by the intracellular pathogen Listeria monocytogenes) compartmentalizes the activity of this toxin and prevents premature destruction of the host cell. To accomplish this, purified and mutagenized listeriolysin O, exchanged mutant alleles into L. monocytogenes, and investigated effects of mutant and native protein expression in tissue culture and animal models. Collaborated synergistically with 3 other laboratory members on this work.
  • The work resulted in 3 original research articles (2 as first author or equivalent), an oral platform presentation at a national meeting, 3 poster presentations at national and international meetings, and numerous other oral presentation venues including NIH Training Grant and School of Public Health seminar series, the UC Berkeley Molecular and Cell Biology departmental retreat, and the HHMI Annual Meeting of Fellows.
  • In response to my competitive grant application titled “Structural Basis of the pH Dependence of the Bacterial Pore-Forming Toxin Listeriolysin O,” was awarded a Howard Hughes Medical Institute Physician Postdoctoral Fellowship (3 years of support). Was also supported by an NIH Infectious Diseases and Virology Training Grant.
  • Spearheaded the laboratory safety program and personally trained each laboratory member with regard to biological, chemical, electrical, and radiation hazards. Trained, supervised and mentored an undergraduate student who subsequently went on to work in a biotech startup, and helped train 7 other graduate students, technicians, and postdocs.
  • This postdoctoral work complemented my rigorous chemistry, biochemistry and biophysics training with hands-on experience in molecular biology and molecular genetics, equipping me to engage researchers from a huge range of disciplines in productive discussions and collaborations.

1986 to 1993
Stanford University, Stanford, CA
Graduate Student, Department of Chemistry
Thesis Advisor: Wray H. Huestis
Thesis: “Cell pH-Mediated Shape Change in the Human Erythrocyte”

  • Solved the paradox of pH-associated red cell shape change by developing assays and mathematical models for red cell physiological relationships, performing nonlinear multivariate statistical analysis on a 500-entry dataset, and assessing red cell protein-membrane interactions using a hydrophobic, radioiodinated, photoactivatable membrane probe. Also, demonstrated the amphipathic nature of chlorpromazine binding to plasma membrane components.
  • Collaborated synergistically with 2 other graduate students on this work.
  • Supervised and mentored an undergraduate student on the red cell shape project, who subsequently went on to medical school. Made numerous research and journal articles presentations to laboratory and departmental groups. Was supported by a Jameson Research Foundation Fellowship.
  • Relevant to psychopharmacology (action of neuroleptics and general anesthetics) and biophysical problems in general. Resulted in 4 poster presentations at national meetings and 5 original research articles, 4 as first author.
  • My advisor thanked me for being a voice of calm and moderation in a group that included several nationalities and some difficult personalities.

1985 to 1986
Stanford University School of Medicine, Stanford, CA
Medical Student Research Assistant, Department of Neurology

  • Developed a chromium-51 assay of damage to cultured neurons and used it to assess glutamate neurotoxicity. Was supported by a Kevin Walton Summer Fellowship. Relevant to stroke, epilepsy and trauma. Resulted in 2 original research articles, 1 as first author.

1984 to 1985
The Rockefeller University, New York, NY
Research Assistant, Laboratory of Metabolism/Pharmacology

  • Performed clinical assays of hemoglobin synthesis pathway enzymes and intermediates using biochemical and organic chemical separations and assays. Relevant to in-born errors of metabolism and hepatic metabolic disorders.

1983 to 1984
Memorial Sloan-Kettering Cancer Center, New York, NY
Research Assistant, Laboratory of Developmental Genetics

  • Studied the molecular basis of a murine developmental defect using tissue culture and protein chemistry approaches. Relevant to congenital disorders and to cancer.

Other Projects

  • TheraSounds™ relaxing at-home hypnotherapy (, using safe and effective hypnotherapy scripts, brainwave entrainment and positive affirmations for personal change.
  • SusPro (, an educational non-profit organization dedicated to developing methods for sustainable housing, energy, and agriculture. I serve as donor and spokesperson for this inspiring and worthy organization. Activities include networking at local and regional functions, and contacting high-priority potential donors.

Honors and Awards

Kevin Walton Summer Fellowship

1990 to 1992
Jameson Research Foundation Fellowship

1995 to 1996
Infectious Diseases and Virology Training Grant (NIH)

1996 to 1999
Howard Hughes Medical Institute Physician Postdoctoral Research Fellowship



Gedde MM. 1993. Cell pH-mediated shape change in the human erythrocyte. Department of Chemistry, Stanford University.

Original Research Articles

  1. Maulucci-Gedde M, Choi DW. 1987. Cortical neurons exposed to glutamate rapidly leak preloaded 51-chromium. Experimental Neurology 96:420-429.
  2. Choi DW, Maulucci-Gedde M, Kriegstein AR. 1987. Glutamate toxicity in cortical cell culture. Journal of Neuroscience 7:357-368.
  3. Gedde MM, Yang E, Huestis WH. 1995. Response of human erythrocyte shape to altered cell pH. Blood 86:1595-1599.
  4. Mazzaccaro RJ, Gedde MM, Jensen ER, van Santen HM, Ploegh HL, Rock KL, Bloom BR. 1996. Major histocompatibility class 1 presentation of soluble antigen facilitated by Mycobacterium tuberculosis infection. Proceedings of the National Academy of Science, USA 93:11786-11791.
  5. Gedde MM, Huestis WH. 1997. Membrane potential and human erythrocyte shape. Biophysical Journal 72:1220-1233.
  6. Gedde MM, Davis DK, Huestis WH. 1997. Cytoplasmic pH and human erythrocyte shape. Biophysical Journal 72:1234-1246.
  7. Gedde MM, Yang E, Huestis WH. 1999. Resolution of the paradox of red cell changes in low and high pH. Biochimica et Biophysica Acta 1417:246-253.
  8. Gedde MM, Higgins DE, Tilney LG, Portnoy DA. 2000. Role of listeriolysin O in cell-to-cell spread of Listeria monocytogenes. Infection and Immunity 68:999-1003.
  9. Glomski IJ,* Gedde MM,* Tsang AW, Swanson JA, Portnoy DA. 2002. The Listeria monocytogenes hemolysin has an acidic pH optimum to compartmentalize activity and prevent damage to infected host cells. Journal of Cell Biology 156:1 12.
    *These authors contributed equally.
  10. Baden LR, Critchley IA, Sahm DF, So W, Gedde M, Porter S, Moellering RC Jr, Eliopoulos G. 2002. Molecular characterization of vancomycin-resistant enterococci repopulating the gastrointestinal tract following treatment with a novel glycolipodepsipeptide, ramoplanin. Journal of Clinical Microbiology 40:1160-3.
  11. Chen JY, Brunauer LS, Chu FC, Helsel CM, Gedde MM, Huestis WH. 2003. Selective amphipathic nature of chlorpromazine binding to plasma membrane bilayers. Biochimica Biophysica Acta (Biomembranes) 1616(1):95-105.

Continuing Education Articles

  1. Gedde MM, Kricka LJ. 1994. Serum ferritin measurement: a case study approach to quality improvement. Endocrinology and Metabolism In-Service Training and Continuing Education 12(7):179-183.
  2. Gedde MM, Kricka LJ. 1994. Rhabdomyolysis. Endocrinology and Metabolism In-Service Training and Continuing Education 12(9):241-246.


Dec 1989
American Society for Cell Biology, Houston, TX
Gedde MM, Huestis WH. “Roles of internal pH, cell volume, and membrane potential in human erythrocyte pH-induced shape change.” Journal of Cell Biology 109:175a.

Feb 1991
Biophysical Society, San Francisco, CA
Gedde MM, Huestis WH. “Human erythrocyte shape change induced by changes in buffer pH is most dependent on changes in cytoplasmic pH.” Biophysical Journal 59:639a.

Dec 1993
American Society for Cell Biology, New Orleans, LA
Gedde MM, Yang E, Huestis WH. “Hydrophobic protein-lipid associations in human erythrocyte cell pH-mediated shape change.” Molecular Biology of the Cell 4:85a.

Dec 1997
American Society for Cell Biology, Washington, D.C
Gedde MM, Higgins DE, Tilney LG, Portnoy DA. “Role of the pore-forming protein, listeriolysin O, in the cell-to-cell spread of Listeria monocytogenes.” Molecular Biology of the Cell 8:237a.

Dec 1998
American Society for Cell Biology, San Francisco, CA
Chen JY, Chu FC, Gedde MM, Huestis WH. "Selective electrostatic interactions of chlorpromazine with plasma membrane components." Molecular Biology of the Cell 9:80a.

Feb 1999
Biophysical Society, Baltimore, MD
Gedde MM, Portnoy DA. “Structural basis of the pH-dependence of the pore-forming protein listeriolysin O.” Biophysical Journal 76:22a.

Feb 2000
1st International ASM Conference on Enterococci, Banff, Alberta, Canada
So W, White DJ, Gedde MM. “Comparison of selective media for isolation of vancomycin-resistant enterococci.” February 27 to March 2, 2000.

Feb 2000
1st International ASM Conference on Enterococci, Banff, Alberta, Canada
Baden L, Critchley I, Sahm D, So W, Gedde MM, Porter S, Moellering RC Jr, Eliopoulos G. “Pulsed-field gel electrophoresis of VRE DNA isolated during a phase II clinical study of the novel glycolipodepsipeptide ramoplanin.” February 27 to March 2, 2000.

May 2000
American Society for Microbiology, Los Angeles, CA
Gedde MM, Glomski IJ, Portnoy DA. “The role of the acidic pH optimum of listeriolysin O in Listeria monocytogenes pathogenesis.” 100th General Meeting. Abstract D-59, p 239.

Sep 2000
Symposium on Pore-Forming Toxins, Trento, Italy
Glomski IJ, Gedde MM, Portnoy DA. “Increasing the hemolytic activity of listeriolysin O at neutral pH decreases the virulence of Listeria monocytogenes.” September 14-17, 2000.

Dec 2000
1st Intl Symposium on Resistant Gram-Positive Infections, San Antonio, TX
White DJ, Visweswaran V, So W, Hurst MA, Gedde MM. “Resistance profile of ramoplanin, a novel glycolipodepsipeptide with selective gram-positive activity.” December 3-5, 2000.

Oct 2001
North American Cystic Fibrosis Conference, Orlando, FL
Loury DL, Gedde MM, Woods DE. "Aerosolized protegrin analog iseganan (IB-367) reduces microbial density in a rat model of lung infection with Pseudomonas aeruginosa." October 25 28, 2001.



Dr. Margaret Gedde, MD, PhD
Gedde Whole Health, LLC

Mailing Address:
8601 W. Cross Dr. #F5-183
Littleton, CO USA 80123

Phone & Fax: (877) 237-8571

Disclaimer: The information contained on this web site has not been evaluated by the FDA. This information is not intended to treat, diagnose, cure or prevent any disease. The material on this web site is provided for educational purposes only. Always seek the advice of your physician or other qualified health care provider with any questions you have regarding a medical condition, and before undertaking any diet, exercise or other health program.

© 2005-2013  Gedde Whole Health, LLC. All rights reserved.
Reproduction in whole or in part without permission is prohibited.
Revised 09/30/2013